Study on MID-IR Spectroscopy on Whole Blood Samples for Human Glucose Quanitification Applications

The importance of a systematic glucose monitoring in order to keep a steady control for diabetic patients has been established. Several medical studies accept the necessity of exploring alternatives for the traditional digital glucometer, given the pain and discomfort related to the application of this technique, which can lead to a compromised control of the disease. Several efforts based on the application of IR spectroscopy have been done with favorable, yet not conclusive results. Therefore it’s necessary to apply a comprehensive and interdisciplinary study based on the biochemical and optical properties of the glucose in the human body in order to understand the interaction between this substance, its surroundings, and IR light. This study proposes a comprehensive approach of the glucose and IR light interaction, considering and combining important biochemical, physiological and optical properties such as the effect of glucose regulation compounds and data mining based chemometrics techniques. The results of this work would help to define the right parameters, aiming to obtain an optical glucose quantification or classification system, as well as the protocol for the purpose.